酒精性肝病患者瘦素水平与肝功能的相关性

目的 探讨瘦素在酒精性肝病(ALD)及不同阶段中的变化规律及其与肝功能受损的关系.方法 采用放射免疫法分别测定22例酒精性脂肪肝(AFD)、11例酒精性肝炎(AH)、13例酒精性肝硬化(AC)患者的血清瘦素水平，同时生化检测46例患者的肝功能，选择30例健康体检者作对照.结果 酒精性肝病患者血清瘦素水平(10.63±4.06 μg/L)明显高于正常对照组(4.98±2.89 μg/L),P<0.05，酒精性肝病患者血清瘦素水平与肝功能受损呈明显相关性.结论 测定血清瘦素水平可用于评估酒精性肝病的病情，对判断预后有参考价值.

Correlative Study of Serum Leptin and Liver Function in Patients with Alcoholic Liver Disease

Objective To study the relation of serum leptin and liver function in patients with alcoholic liver disease(ALD).Methods The levels of serum leptin and liver function were measured by radioimmunoassay(RIA) and the sequential multiple autoanalyzer in patients with ALD,including 22 alcoholic fatty liver(AFL),11 alcoholic hepatitis(AH),13 alcoholic cirrhosis(AC)and 30 healthy control groups.Results The levels of serum leptin in patients with ALD were higher than that of normal control group.The levels of leptin were significantly related to liver function in patients with ALD.Conclusion The levels of serum leptin may be an indication of liver function in patients with ALD.