| 环境污染物PFOS可引起大鼠海马干细胞的增殖 |
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| 引用本文： | 王昕,陈誉华.环境污染物PFOS可引起大鼠海马干细胞的增殖[J].辽宁大学学报(自然科学版),2010,37(4):294-297. |
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| 作者姓名： | 王昕 陈誉华 |
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| 作者单位： | 中国医科大学基础医学院发育生物教研室,卫生部细胞生物学重点实验室,辽宁沈阳110001 |
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| 摘 要： | 目的:观察全氟辛烷磺酰基化合物(PFOS)大鼠海马干细胞增殖情况.方法:利用大鼠腹腔内连续注射不同剂量的PFOS 14天,建立动物模型.以Brdu作标记物,利用免疫组织化学染色的方法检测不同剂量PFOS作用下大鼠海马干细胞增殖情况.结果:以Brdu作标记物,高剂量PFOS作用下大鼠海马内可检测到大量阳性细胞存在,对照组和低剂量PFOS作用下无此阳性结果产生.结论:推测PFOS可引起大鼠海马干细胞的增殖.
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| 关 键 词： | 全氟辛烷磺酰基化合物（PFOS） 大鼠海马 干细胞 增殖 |
Perfluorooctanesulfonate(PFOS) Can Lead to the Proliferation of Rats' hippocampus Stem Cell |
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| WANG Xin,CHEN Yu-hua.Perfluorooctanesulfonate(PFOS) Can Lead to the Proliferation of Rats' hippocampus Stem Cell[J].Journal of Liaoning University(Natural Sciences Edition),2010,37(4):294-297. |
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| Authors: | WANG Xin CHEN Yu-hua |
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| Institution: | (Developmental Biology Department,Key Lab of Cell Biology,Ministry of Public Health of China,China Medical University,Shenyang 110001,China) |
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| Abstract: | Objective：In order to observe the proliferation of rats＇ hippocampus stem cell by continuous abdominal injection of Perfluorooctanesulfonate（PFOS）.Methods：Set up animal model by continuous abdominal injection of different doses of PFOS for 14 days.Take Brdu as a marker,detect the proliferation of rats＇ hippocampus stem cell under the induction of different doses of PFOS by immunohistochemistrys.Result： Take Brdu as a marker,In high dosage positive cells were found in rats＇ hippocampus stem cell under the induction of PFOS,not in the low dosage and control group.Conclusion： PFOS can lead to the proliferation of rats＇ hippocampus stem cell |
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| Keywords: | Perfluorooctanesulfonate（PFOS） rats＇ hippocampus stem cell proliferation |
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