| 胆碱酯酶催化反应的量子化学研究——底物对组氨酸、丝氨酸残基间氢迁移的影响 |
| |
| 引用本文： | 苏忠民,崔瑞海,王春宝,王丽梅.胆碱酯酶催化反应的量子化学研究——底物对组氨酸、丝氨酸残基间氢迁移的影响[J].东北师大学报(自然科学版),1992(2). |
| |
| 作者姓名： | 苏忠民 崔瑞海 王春宝 王丽梅 |
| |
| 作者单位： | 东北师大化学系，东北师大化学系，东北师大化学系，东北师大化学系 |
| |
| 摘 要： | 本文考虑到底物的影响,对胆碱酯酶酯解部位的组氨酸、丝氨酸等残基问的氢键问题,继前文进行了深入的探讨,用量子化学理论进一步阐明乙酰胆碱酶催化水解反应的机理.指出丝氨酸残基的羟基在进攻底物的过程中逐步把氢原子转移给组氨酸残基.
|
| 关 键 词： | 胆碱酯酶 底物 氢键 CNDO/2 |
A QUANTUM CHEMTSTRY STUDY OF CHOLINESTERASE: THE HYDROGEN BONDING AND PROTON TRANSFER BETWEEN HISTICLINE AND SERINE RESIDUES UNDER THE INFLUENCE OF SUBSTRATE |
| |
| Su Zhongmin,Cui Ruihai,Wang Cunbao,Wang Limei.A QUANTUM CHEMTSTRY STUDY OF CHOLINESTERASE: THE HYDROGEN BONDING AND PROTON TRANSFER BETWEEN HISTICLINE AND SERINE RESIDUES UNDER THE INFLUENCE OF SUBSTRATE[J].Journal of Northeast Normal University (Natural Science Edition),1992(2). |
| |
| Authors: | Su Zhongmin Cui Ruihai Wang Cunbao Wang Limei |
| |
| Institution: | Su Zhongmin;Cui Ruihai;Wang Cunbao;Wang Limei |
| |
| Abstract: | In this paper,we discuss the hydrogen bonding between histicline and serine residues of the cholinesterase ester active sites through the quantum chemistry calculation(CNDO/2). From the theoretical point of view,we study how the substrate influence the nucleophilic groups that attack the substrate in the acetylcholine catalized hydrolysis reaction,and we obtain some meaningful results. |
| |
| Keywords: | Cholinesterase Substrate Hydrogen bonding CNDO/2 |
| 本文献已被 CNKI 等数据库收录！ |
