The effects of various agents in vitro on homocarnosine-carnosine synthetase from rat brain |
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| Authors: | R H Ng F D Marshall |
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| Institution: | (1) Department of Biochemistry, The University of South Dakota School of Medicine, 57069 Vermillion, South Dakota, USA |
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| Abstract: | Summary The present paper reports the first evidence that homocarnosine-carnosine synthetase from rat brain requires free sulfhydryl groups for activity. The activity of the synthetase can be stabilized by dithioerythritol and inhibited strongly by Cu2+, Cd2+, Hg2+, Zn2+, and to a lesser extent by Ca2+, Ni2+, Li, chlorpromazine,  -methyl DOPA and norepinephrine at the concentrations tested.Acknowledgment. This work was supported by United States Public Health Service Grant No. NS-06137. |
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