| Recent progress in the study of intracellular toxicity of amyloid P peptide in Alzheimer's disease |
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| 作者姓名： | ZHANG Yan and YU Longchuan |
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| 作者单位： | College of Life Sciences，Peking University，Beijing 100871，China |
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| 基金项目： | Supported by National Natural Science Foundation of China (Grant No. 30540023)，Peking University President Research Grant and National Program on Key Basic Research Project, Ministry of Science and Technology of China (Grant No. 2006CB500700) |
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| 摘 要： | Amyloidβ(Aβ) deposition is one of the major pathological markers of Alzheimer's disease (AD). Extracellular Afi toxi-city has been studied for a long time in AD research field. However, controversial data show that extracellular Aβload does not correlate with the dementia levels of AD patients and extracellular Aβonly induces significant cell death at non-physiological high concentrations. With the evolvement of Afi hypothesis, considerable attention has been devoted to the study of intracellular Aβtoxicity recently. Intracellular Aβinduces dramatic cell loss in AD transgenic models and in human primary neurons (at pM concentrations) through p53, Bax and caspase-6 pathways. Here, we review the generation, toxicity and possible pathways of intracellular Aβtoxicity, and discuss the implication and current knowledge of intracellular Aβin neuronal cell loss in neurodegenerative diseases.
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Recent progress in the study of intracellular toxicity of amyloid P peptide in Alzheimer's disease |
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| ZHANG Yan and YU Longchuan.Recent progress in the study of intracellular toxicity of amyloid P peptide in Alzheimer's disease[J].Progress in Natural Science,2007(3). |
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| Authors: | ZHANG Yan and YU Longchuan |
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| Abstract: | |
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| Keywords: | Alzheimer's disease amyloid P peptide neruonal loss |
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