Application of modified amino acid as a chiral building block in asymmetric synthesis |
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Authors: | Jianping Wang Xiyun Zhang Qinghua Chen |
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Institution: | (1) Department of Chemistry, Beijing Normal University, 100875 Beijing, China;(2) Department of Chemistry, Luoyang Teacher’s College, 471022 Luoyang, China |
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Abstract: | Phenylglycine 1 as a representative of natural resourceful α-amino acid was modified by reduction and protection of functional
group to afford the amino alcohol as a chiral building block 3. A new chiral compound, the chiral building block/spiro-cyclopropane
derivative containing four stereogenic centers, compound 7, has been obtained in 52% yield with de⩾98% via the tandem double
Michael addition/internal nucleophilic substitution under mild condition of 5-l-menthyloxy-3-bromo-2-(5H)-furanone 4 with the nucleophilic reagent, the amino alcohol 3. The new chiral compound 7 is identified
on the basis of its analytical data and spectroscopic data, such as UV, IR,1H NMR,13C NMR, MS and elementary analysis. The absolute configuration of the interesting spiro-cyclopropanes 7 was established by
X-ray crystallography. This result can provide new route and method for the introduction of chiral building block and the
important synthetic strategy in synthesis of some complex molecules containing spiro-cyclopropane skeleton with multiple chiral
centers and the study of their biological activity. |
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Keywords: | modified α -amino acid phenylglycine amino alcohol chiral building block spiro-cyclopropane derivative stereochemistry absolute configuration |
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