Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist |
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| Authors: | K Damm C C Thompson R M Evans |
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| Affiliation: | Gene Expression Laboratory, Howard Hughes Medical Institute, La Jolla, California. |
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| Abstract: | The thyroid-hormone receptor can, in the absence of its ligand, suppress activity of a responsive promoter. Addition of thyroid hormone, however, results in the stimulation of expression. The oncogenic derivative of the thyroid-hormone receptor, v-erbA, acts as a constitutive repressor and, when coexpressed with the receptor, blocks activation by thyroid hormone. Thus, v-erbA may be the first example of a dominant negative oncogene. |
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