| （口恶）二唑硫醚基型6-取代吲哚衍生物的合成和抗菌活性研究 |
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| 引用本文： | 刘兴利,石治川,赵志刚,王稚京,叶英.（口恶）二唑硫醚基型6-取代吲哚衍生物的合成和抗菌活性研究[J].西南民族学院学报(自然科学版),2013(6):877-880. |
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| 作者姓名： | 刘兴利 石治川 赵志刚 王稚京 叶英 |
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| 作者单位： | 西南民族大学化学与环境保护工程学院,成都610041 |
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| 基金项目： | 四川省应用基础研究项目（No.2012JY0028） |
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| 摘 要： | 以6-吲哚甲酸甲酯为起始原料,高产率的合成了9个新的含（口恶）二唑硫醚基结构的6-吲哚衍生物,其结构均经核磁,质谱,红外光谱和元素分析确证.抗菌活性实验表明,所合成的目标物对大肠杆菌（E.coli）具有较好的抗菌活性.
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| 关 键 词： | 6-吲哚甲酸甲酯 （口恶）二唑 抑菌活性 |
Synthesis and antibacterial activities of 6-substituted indole derivatives containing oxadiazole and sulfide units |
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| LIU Xing-li,SHI Zhi-chuan,ZHAO Zhi-gang,WANG Zhi-jing,YE Ying.Synthesis and antibacterial activities of 6-substituted indole derivatives containing oxadiazole and sulfide units[J].Journal of Southwest Nationalities College(Natural Science Edition),2013(6):877-880. |
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| Authors: | LIU Xing-li SHI Zhi-chuan ZHAO Zhi-gang WANG Zhi-jing YE Ying |
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| Institution: | (School of Chemistry and Environmental Protection Engineering, Southwest University tbr Nationalities, Chengdu 610041, P. R. C.) |
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| Abstract: | A new type of 6-indole derivatives containing oxadiazole and sulfide units are synthesized in good yields by using methyl indole-6-carboxylate as starting material. The structures of the new compounds are characterized by IH NMR, MS, IR and elemental analysis. The antibacterial activities are investigated against E. coli and S. aureus bacteria. The results indicate that these compounds have good antibacterial effects for E. coli. |
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| Keywords: | methyl indole-6-carboxylate oxadiazole inhibitive activity |
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