| 聚L-乳酸药用辅料的吸湿特性 |
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| 引用本文： | 马建华,鲍时根,朱玉俊.聚L-乳酸药用辅料的吸湿特性[J].安徽理工大学学报(自然科学版),2006,26(2):61-64. |
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| 作者姓名： | 马建华 鲍时根 朱玉俊 |
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| 作者单位： | 安徽理工大学化学工程系,安徽,淮南,232001;合肥工业大学控释药物研究室,安徽,合肥,230009 |
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| 摘 要： | 考察聚L-乳酸药用辅料在潮湿空气和水中的吸湿特性.测定了不同分子量的粉料与片状试样在不同相对湿度的空气与蒸馏水中的吸湿量与时间的关系,得出平衡湿含量,并计算出水分在试样中的扩散系数.粉料与片状试样在不同湿度的湿空气中的平衡湿含量均小于1%,在水中的平衡湿含量小于11%,辅料分子量对吸湿性能有一定影响.吸湿过程遵从Fick扩散机理.
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| 关 键 词： | 聚L-乳酸 吸湿性 平衡湿含量 Fick扩散 |
| 文章编号： | 1672-1098(2006)02-0061-04 |
| 收稿时间： | 2005-08-19 |
| 修稿时间： | 2005年8月19日 |
Moisture Absorption Properties of Poly(L- lactic acid)Used as an Excipient |
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| MA Jian-hua,BAO Shi-gen,ZHU Yu-jun.Moisture Absorption Properties of Poly(L- lactic acid)Used as an Excipient[J].Journal of Anhui University of Science and Technology:Natural Science,2006,26(2):61-64. |
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| Authors: | MA Jian-hua BAO Shi-gen ZHU Yu-jun |
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| Institution: | 1. Dept. of Chemical Engineering , Anhui University of Science and Technology, Huainan Anhui 232001, China; 2. Institute of Controlled Release Drug,Hefei University of Technology,Hefei Anhui 230009,China |
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| Abstract: | To evaluate the moisture absorption properties of poly(L-lactic acid)(PLLA) in the moist air and water,PLLAs with different molecule weight as experimental materials were exposed to moist air with different relative humidity and immersed in distilled water,and moisture absorption tests were performed to determine the relationship between moisture content and time.The equilibrated moisture contents were measured and the moisture diffusibilities into the samples were calculated with the results obtained from the tests above.No mater what powdery PLLA and PLLA tables were exposed to moist air with different relative humidity,values of the equilibrated moisture contents were all below 1% and the values below 11% when immersed in the water.Molecule weight of PLLA influenced on moisture absorption properties to a certain extent.The process of moisture absorption matches Fickian diffusion mechanism. |
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| Keywords: | poly(L-lactic acid) moisture absorption propoerties equilibrated moisture contents Fickian diffusion |
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