Following evolution of bacterial antibiotic resistance in real time |
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Authors: | Rosenthal Adam Z Elowitz Michael B |
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Institution: | Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, California, USA. |
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Abstract: | A new study reports the development of the 'morbidostat', a device that allows for continuous culture of bacteria under a constant drug selection pressure using computer feedback control of antibiotic concentration. This device, together with bacterial whole-genome sequencing, allowed the authors to follow the evolution of resistance-conferring mutations in Escherichia coli populations in real time, providing support for deterministic evolution of resistance in some situations. |
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