On the metabolism of prostaglandins by rat brain homogenate

Summary Using radio-immuno assays for prostaglandins and prostaglandin metabolites, three prostaglandin metabolizing enzymes were found in the 100,000×g supernatant of rat brain, 15-hydroxy-prostaglandin-dehydrogenase, ¹³ and prostaglandin E-9-keto-reductase. Specific activity of the latter enzyme was highest in striatum and midbrain and lowest in cortex, cerebellum and spinal cord.This work was supported by the Deutsche Forschungsgemeinschaft (SFB No. 70).