| 双官能化的L-脯氨酰胺催化不对称直接Aldol反应 |
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| 引用本文： | 郭川胜 刘全忠 王雪莲 何龙 王振雷. 双官能化的L-脯氨酰胺催化不对称直接Aldol反应[J]. 西华师范大学学报(哲学社会科学版), 2007, 28(2): 172-176 |
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| 作者姓名： | 郭川胜 刘全忠 王雪莲 何龙 王振雷 |
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| 作者单位： | 西华师范大学化学化工学院 四川南充637002 |
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| 摘 要： | Boc保护的L-脯氨酸与光学活性联二萘酚衍生的胺类化合物反应,经过脱去Boc保护基和甲基制得了四个脯氨酰胺类化合物.考察了其不对称催化直接Aldol反应性能,构型匹配的催化剂得到相对较高的对映选择性.催化丙酮和对硝基苯甲醛的反应,最高得到了57%的产率和40%的对映体过量.
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| 关 键 词： | 双官能化 脯氨酰胺类化合物 不对称催化 直接Aldol反应 |
| 文章编号： | 1673-5072（2007）02-0172-05 |
| 修稿时间： | 2006-12-30 |
Bifunctional L-Prolinamide Catalyzed Asymmetric Direct Aldol Reaction |
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| GUO Chuan-sheng, LIU Quan-zhong , WANG Xue-lian, HE Long and WANG Zhen-lei. Bifunctional L-Prolinamide Catalyzed Asymmetric Direct Aldol Reaction[J]. Journal of China West Normal University:Natural Science Edition, 2007, 28(2): 172-176 |
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| Authors: | GUO Chuan-sheng LIU Quan-zhong WANG Xue-lian HE Long WANG Zhen-lei |
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| Affiliation: | College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002, China |
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| Abstract: | Four prolinamides were prepared by the condensation of the Boc protected L-proline with amides derived from optically pure 1,1'-binaphthy-2,2'-diol,and then submission of deprotection of Boc and methyl group.Their catalytic performance in direct Aldol reaction was also examined as well.The reaction of acetone with p-nitrobenzaldehyde provided up to 57 % yield and up to 40 % ee. |
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| Keywords: | bifunctional prolinamide compounds asymmetric catalysis direct Aldol reaction. |
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