正畸牙移动过程中龈沟液白细胞介素-8的变化

细胞因子白细胞介素-8(Interleukin-8,IL-8)被认为是重要的牙槽骨吸收调节因子,为评价正畸牙移动过程中牙周组织IL-8的水平,选择17颗需远中移动的正畸尖牙,酶联免疫吸附测定法定量分析加力前与加力后1 h、24 h、7 d、14 d及30 d龈沟液中IL-8含量的变化.结果显示:牙受力后1 h、24 h及7 d IL-8含量均较受力前显著增加(p<0.05),且在24 h达到峰值(p<0.01).表明在正畸加力初期,牙周组织IL-8含量显著增加.说明牙周组织对正畸力的生物应答反应导致IL-8增加和中性粒细胞聚集,这可能是骨改建的触发因素之一.

Levels of Interleukin-8 in Gingival Crevicular Fluid During Orthodontic Tooth Movement

Interleukin-8(IL-8) is considered to be important in regulating alveolar bone resorption during tooth movement.The aim of this study was to evaluate the levels of IL-8 in periodontal tissues at different stages of orthodontic tooth movement.Seventeen canine teeth of patients that need to be moved distally were selected for the study.The gingival crevicular fluid(GCF) was taken at baseline and at 1 h,24 h,7 d,14 d and 30 d respectively after initiation of the experiment.The levels of IL-8 in GCF were determined by enzyme-linked immunosorbent assay.The results showed that levels of IL-8 is greater at one hour,24 h and 7 d after applying orthodontic force than the baseline(p<0.05),whereas the highest level of Interleukin-8 was observed at 24 h(p<0.01).The study showed that the levels of IL-8 in periodontal tissues were significantly increased at the early stage of applying orthodontic force.Implication biological response of periodontal tissues toward the orthodontic forces might lead an increase in IL-8 and neutrophil accumulation,and this may be one of the triggers for bone remodeling processes.