The pharmacological effect of fractions obtained by smoking cannabis through a water-pipe. II. A second fractionation step |
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| Authors: | H. Lazaratou A. Moschovakis A. Armaganidis V. Kapsambelis J. Kiburis T. A. Kephalas |
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| Affiliation: | (1) Department of Biological Chemistry, Medical School, University of Athens, Goudi 609, Athens, (Greece) |
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| Abstract: | Summary The catatonic activity, prolongation of phenobarbital sleeping-time, convulsant action and disruption of nestbuilding activity were assessed in mice subjected to 4 cannabis pyrolysis products and their tobacco analogues. All but one of the cannabis fractions prolonged the pentobarbital sleeping-time and disrupted the nest-building activity of mice in a way not related to their content in the main cannabinoids. Nest-building activity seems to be the most valid assay we have used so far. |
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