| 阿特拉津对发育期SD大鼠免疫功能的影响 |
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| 引用本文： | 邴志桐,李研超,司万童,张迎梅.阿特拉津对发育期SD大鼠免疫功能的影响[J].兰州大学学报(自然科学版),2009,45(1). |
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| 作者姓名： | 邴志桐 李研超 司万童 张迎梅 |
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| 作者单位： | 兰州大学生命科学学院,甘肃,兰州,730000 |
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| 摘 要： | 研究了除草剂阿特拉津对发育期雌、雄SD大鼠免疫功能的影响.选用雌雄SD大鼠(80±10 g)各32只,分别分为4组,每组8只.根据体重比设置对照、低、中、高剂量处理组(0,25,125,250mg/kg)进行(阿特拉津)染毒,30 d后测定雌雄大鼠脾脏、胸腺和体重的相对比值.同时取外周血,培养细胞后测定淋巴细胞转化率和半数溶血素值.结果表明:对雌雄大鼠,阿特拉津对脾脏均没有影响,但对胸腺具有显著的损伤作用(P<0.05),使其发生退行性病变;淋巴细胞转化率(刺激指数s,值)在中、高剂量组的雌鼠和雄鼠中均显著下降(P<0.05),且雌雄间差异显著(P<0.05).对半数溶血素值的测定结果表明:中、高剂量组与对照组相比均明显下降(P<0.01).阿特拉津对大鼠的免疫系统具有显著的毒性效应,推测雌雄间的差异与雌激素水平有关.
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| 关 键 词： | 阿特拉津 SD大鼠 脏器比重 淋巴细胞转化率 血清半数溶血素 |
Effects of chronic Atrazine exposure on immunological function in SD rats in developing period |
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| BING Zhi-tong,LI Yan-chao,SI Wan-tong,ZHANG Ying-mei.Effects of chronic Atrazine exposure on immunological function in SD rats in developing period[J].Journal of Lanzhou University(Natural Science),2009,45(1). |
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| Authors: | BING Zhi-tong LI Yan-chao SI Wan-tong ZHANG Ying-mei |
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| Institution: | School of Life Sciences;Lanzhou University;Lanzhou 730000;China |
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| Abstract: | The effects of Atrazine on the immunological function in developing SD rats were investigated. SD rats were randomly divided into 4 groups with different Atrazine dose,i.e.the control group(0 mg/kg), low-dose group(25 mg/kg),middle-dose group(125 mg/kg),high-dose group(250 mg/kg).There were equal number of males and females in each group.The ratio of weight to different organs was assayed after a 30-day exposure.In order to investigate the level of immunity of rats,the lymphocyte proliferation value(SI) and... |
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| Keywords: | Atrazine SD rat ratio of organs lymphocyte proliferation hemolysin |
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