抗心磷脂抗体与不明原因复发性自然流产的相关性研究

目的 探讨抗心磷脂抗体在不同孕育状态下妇女人群中的表达情况,研究抗心磷脂抗体与复发性自然流产的相关性.方法 应用前瞻对照的研究方法,收集正常生育组、早初孕组、复发性自然流产组、继发不孕组、偶发流产组5组病例.采用ELISA法检测各组病例中的抗心磷脂抗体IgG、IgM、IgA.运用统计软件,以x2检验分析各组抗心磷脂抗体IgG、IgM、IgA阳性率的差别.结果 得到抗心磷脂抗体IgG、IgM、IgA的阳性率,正常生育组：0.00％、3.70％、3.70％；早初孕组：0.94％、4.72％、0.94％；复发性自然流产组：9.76％、7.32％、2.44％；继发不孕组：3.57％、1.79％、3.57％；偶发流产组：0.00％、3.70％、7.41％.RSA组与早孕组均有统计学意义,p＜0.05；余组间比较无统计学意义.结论 抗心磷脂抗体阳性率在RSA最高19.52％、早初孕组6.60％、继发不孕组8.93％、偶发流产组11.11％、正常生育组7.40％.不明原因复发性自然流产的发生和抗心磷脂抗体的产生密切相关.

Research of unexplained recurrent spontaneous abortion with anti-cardiolipin antibodies

Abstract ：Objective To study expression of anticardiolipin antibodies in the population of women gave birth to the state, and the correlation of anticardiolipin antibodies and recurrent spontaneous abortion. Methods Prospective controlled study, the collection of normal fertility group, five patients as early as the beginning of pregnancy, recurrent spontaneous abortion, secondary infertility, INCIDENTAL abortion group. Detected by ELISA in each group of patients in the anti-cardiolipin antibodies IgG, IgM, IgA. Using statistical software, x-test to analyze the difference of positive rates in each group of anticardiolipin antibody IgG, IgM, IgA. Results The positive rates of anti-cardiolipin antibodies IgG, IgM, IgA are, normal fertility group： 0. 00%, 3. 70%, 3. 70%, as early as the beginning of pregnancy group： 0. 94%, 4. 72%, 0. 94%, recurrent spontaneous abortion group： 9.76%, 7. 32%, 2.44%, secondary infertility group： 3. 57%, 1. 79%, 3.57%, sporadic abortion group： 0. 00%, 3. 70%, 7. 41%. RSA patients with early pregnancy group were statistically significant （p〈0.05）; I groups was not statistically significant. Conclusion Anticardiolipin antibody positive rate in RSA is up to 19.52%, as early as the beginning of pregnancy group 6.60% ,while 8.93 % of secondary infertility group, 11.11% of sporadic abortion group, 7.40 % of the normal fertile group. Unexplained recurrent spontaneous abortion and anti-cardiolipin antibodies are closely related.