| 含氮羧酸的羟乙基甲硝唑酯的合成 |
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| 引用本文： | 赵宪瑞,李崇熙.含氮羧酸的羟乙基甲硝唑酯的合成[J].北京大学学报(自然科学版),2002,38(2):175-180. |
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| 作者姓名： | 赵宪瑞 李崇熙 |
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| 作者单位： | 北京大学化学与分子工程学院,北京,100871 |
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| 摘 要： | 为寻找羟乙基甲硝唑的替代物,分别采用酸酐法、酰氯法或DCC法,将氨基羧酸与羟乙基甲硝唑反应,得到5个亲水性不同的单酯或二酯,用MS谱确证了次氨基三乙酸与乙酸酐反应的中间物,并对得到的酯的1H-NMR谱进行了初步研究.3个二酯中,有2个未见文献报道.
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| 关 键 词： | 羟乙基甲硝唑 α-氨基羧酸 氨基酸 二酯 |
Synthesis of Some Esters of Acids Containing Nitrogen with Metronidazole |
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| ZHAO Xianrui\ LI Chongxi\.Synthesis of Some Esters of Acids Containing Nitrogen with Metronidazole[J].Acta Scientiarum Naturalium Universitatis Pekinensis,2002,38(2):175-180. |
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| Authors: | ZHAO Xianrui\ LI Chongxi\ |
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| Institution: | ZHAO Xianrui\ LI Chongxi\+* |
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| Abstract: | In order to find replacer for Metronidazole and drug selection.Some diesters or esters of acids containing nitrogen with Metronidazole were designed and synthesized,which have difference in water\|solubility.Metronidazole was reacted with the corresponding amino or imino multi\|carboxylic acid compounds in the presence of acetic anhydride or thionyl chloride or DCC.The intermediate of nitrilotriacetic acid with Ac\-2O was identified by Mass Spectrum.Out of three diesters two are novel. |
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| Keywords: | Metronidazole amino carboxylic acid amino acid diester |
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