力竭运动对大鼠骨骼肌肌浆网钙转运的影响

采用递增负荷力竭运动方式观察急性运动对肌浆网(SR)钙转运能力的影响,发现运动后股四头肌SR Ca2+-ATPase活性和Ca2+摄取速率均明显下降,表现为SR Ca2+-ATPase活性和Ca2+摄取速率分别下降51.12%(P<0.01)和17.72%(P<0.01);而脂质过氧化物浓度则显著升高,增加48.85%(P<0.01).提示急性运动后SR Ca2+-ATP ase 活性和Ca2+摄取速率下降可能是脂质过氧化增高的结果,而Ca2+摄取功能下降可能与运动性疲劳密切相关.

Effects of exhausted exercise on Ca transport of sarcoplasmic reticulum of skeletal muscles in rats

Sarcoplasmic reticulum plays an important role in regulating the contraction-relaxation of skeletal muscles.This paper studied the effects of acute exercise on SR Ca transport capacity of skeletal muscles of rats. It was found that the SR Ca 2 -ATP ase activity(51.12%P<0.01) and Ca 2 uptake rate(17.72%P<0.01) were decreased significantly after exhausted running;but the content of lipid peroxide in sarcoplasmic reticulum from the exercise group rats was significantly higher than that from the controlled rats(48.85% P<0.01). The results suggested that the enhancement of lipid peroxidation via the exercise animals might be responsible for the decreases of Ca 2 -ATP ase activity and Ca 2 uptake rate in sarcoplasmic reticulum in the exercise animals,the reduction of SR Ca 2 uptake rate might be closely related to exercise-induced skeletal muscle fatigue.