| Permeation of vanadium(III,IV,V)-dipicolinate complexes across MDCK cell monolayer and comparison with Caco-2 cells |
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| 作者姓名： | ZHANG Yue YANG Xiaoda & WANG Kui . |
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| 作者单位： | ZHANG Yue1，YANG Xiaoda1，2 & WANG Kui1，2 1. Department of Chemical Biology，Laboratory of Preventive Pharma-ceutics，School of Pharmaceutical Science，Peking University，Beijing 100083，China; 2. National Laboratory of Natural and Biomimetic Drugs，School of Pharmaceutical Science，Peking University，Beijing 100083，China |
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| 摘 要： | In resent years, great attention has been paid to the in-sulin-mimetic property of various vanadium compounds. Although the mechanism of the hypoglycemic effect of vanadium compounds has not been elucidated, the major problems limiting further clinical applications for inor-ganic vanadium compounds include low oral absorption (<10%)1] and gastrointestinal stress2―5]. Hence, a series of vanadium complexes with organic ligands have been syn-thesized, such as bis(maltolato) oxovanadium(IV) (V…
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Permeation of vanadium(III, IV, V)-dipicolinate complexes across MDCK cell monolayer and comparison with Caco-2 cells |
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| ZHANG Yue,YANG Xiaoda, & WANG Kui, ..Permeation of vanadium(III,IV,V)-dipicolinate complexes across MDCK cell monolayer and comparison with Caco-2 cells[J].Chinese Science Bulletin,2005,50(17). |
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| Authors: | ZHANG Yue YANG Xiaoda & WANG Kui |
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| Institution: | ZHANG Yue1,YANG Xiaoda1,2 & WANG Kui1,2 1. Department of Chemical Biology,Laboratory of Preventive Pharma-ceutics,School of Pharmaceutical Science,Peking University,Beijing 100083,China, 2. National Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Science,Peking University,Beijing 100083,China |
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| Abstract: | |
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| Keywords: | vanadium complex MDCK Caco-2 intestinal absorp-tion diabetes |
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