动脉粥样硬化斑块在血流作用下的应力分析

分析血流作用下动脉硬化斑块的应力分布,对动脉粥样硬化斑块失稳破裂的风险评估有重要理论和实际意义。本文基于有限元法,从生物力学角度,对几种常见的动脉粥样硬化斑块模型在血流作用下的应力分布进行数值计算。结果表明:斑块肩部所受应力最大,相应的应力矩最大,其次是沿斑块两肩部连线方向具有较大的应力分布;在大小不同的连带体斑块中,前部小斑块所受应力相对较大。本文模型能较好地解析血管内因动脉粥样硬化斑块的大破裂、形成继发性血栓、爆发急性心肌梗死和脑卒中等心脑血管疾病现象,可为动脉硬化斑块的不稳定性及可能的破裂提供预测。

ANALYSIS OF STRESS OF ATHEROSCLEROTIC PLAQUE UNDER BLOOD FLOW

It is important to study of the stress distributionof atherosclerotic plaque (AP)both in theory and practice on predicting of AP instability and rupture under blood flow. The finite element method is used to compute the stress of different AP models exerted by blood pressure. The results show that the maximum stress concentration occurs in AP shoulderwhich results in a large torque. Secondly, a larger stress distribution can be foundedalong the direction of two shoulders of atherosclerotic plaque. There is a relatively large stress distribution in smaller partin an AP combination structural. The model can describe the acute CCVD appearancewell, which is produced bythe plaque disruptionleading to the acute coronary syndromes of, myocardial infarction, and sudden stroke. The results showed that mechanical stresses in AP play an important rolein AP ruptureprocess and may be used for predicting plaque vulnerability and rupture.