| 影响肝素钠稳定性因素的研究 |
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| 引用本文： | 左勇,潘训海.影响肝素钠稳定性因素的研究[J].四川理工学院学报(自然科学版),2009,22(6):67-69. |
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| 作者姓名： | 左勇 潘训海 |
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| 作者单位： | 1. 四川理工学院生物工程学院,四川,自贡,643000
2. 四川理工学院化学与制药工程学院,四川,自贡,643000 |
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| 摘 要： | 文章研究了温度、pH值、光照、抗氧化剂、氧化剂和离子强度等因素对肝素钠的稳定性影响。结果表明,肝素钠适宜低温条件下保存;最适pH为7-8;抗氧化剂Vc和光照对肝素钠稳定性均无显著影响;氧化剂H_2O_2和高离子强度对肝素钠的稳定性影响较大,而亚硫酸氢钠对肝素钠的稳定性的影响较小。
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| 关 键 词： | 肝素钠 稳定性 结晶紫 分光光度法 |
Study on the Factors Influencing the Stability of Heparin Sodium |
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| ZUO Yong,PAN Xun-hai.Study on the Factors Influencing the Stability of Heparin Sodium[J].Journal of Sichuan University of Science & Engineering:Natural Science Editton,2009,22(6):67-69. |
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| Authors: | ZUO Yong PAN Xun-hai |
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| Abstract: | The factors that could influence the stability of heparin sodium were studied in the paper,which include temperature, pH,light,antioxidant,oxidant,ionic strength.The result showed that heparin sodium should be hold with low temperature,the pH was 7-8,antioxidant(vitamin C),illumination,and NaHSO_3had less influence to the stability of heparin sodium,oxidant(H_2O_2),but ionic strength had more influence to stability of Heparin sodium. |
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| Keywords: | heparin sodium stability crystal violet spectrophotometry |
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