Melanocortin control of energy balance: evidence from rodent models |
| |
Authors: | Bart C De Jonghe Matthew R Hayes Kendra K Bence |
| |
Institution: | (1) Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;(2) Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; |
| |
Abstract: | Regulation of energy balance is extremely complex, and involves multiple systems of hormones, neurotransmitters, receptors,
and intracellular signals. As data have accumulated over the last two decades, the CNS melanocortin system is now identified
as a prominent integrative network of energy balance controls in the mammalian brain. Here, we will review findings from rat
and mouse models, which have provided an important framework in which to study melanocortin function. Perhaps most importantly,
this review attempts for the first time to summarize recent advances in our understanding of the intracellular signaling pathways
thought to mediate the action of melanocortin neurons and peptides in control of longterm energy balance. Special attention
will be paid to the roles of MC4R/MC3R, as well as downstream neurotransmitters within forebrain and hindbrain structures
that illustrate the distributed control of melanocortin signaling in energy balance. In addition, distinctions and controversy
between rodent species will be discussed. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|