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经纤维支气管镜灌注纤维蛋白原、凝血酶治疗咯血的疗效观察
引用本文:周敏,袁民宇,崔小川,胡懋琳.经纤维支气管镜灌注纤维蛋白原、凝血酶治疗咯血的疗效观察[J].江南大学学报(自然科学版),2003,2(3):327-329.
作者姓名:周敏  袁民宇  崔小川  胡懋琳
作者单位:无锡市第五人民医院,呼吸科,江苏,无锡,214073
基金项目:无锡市科委立项科研课题(WZ2001667)
摘    要:目的 旨在为临床治疗咯血寻求更有效的方法及药物,方法 将83例患者随机分成4组,组1经纤维支气管镜(FB)局部灌注纤维蛋白原+凝血酶;组2经FB局部灌注凝血酶;组3予垂体后叶素+常规止血药(止血敏、止血芳酸)静脉滴注;组4予常规止血药静脉滴注。结果 统计学检验显示,4种治疗方法疗效差别有显著性(P=0.0001)。组1、组2的治疗方法优于组3、组4(P<0.05)。而组1较组2疗效更优(P=0.05)。结论 经FB局部灌注凝血药物的止血效果优于静脉用药;经FB灌注纤维蛋白原+凝血酶比单用凝血酶的止血效果更显著。

关 键 词:咯血  纤维支气管镜  纤维蛋白原  凝血酶
文章编号:1671-7147(2003)03-0327-03
修稿时间:2003年3月22日

An Observation of the effectiveness in the Treatment of Hemoptysis by Fibrinogen and Thrombin via Bronchoscopy
ZHOU Min,YUAN Min-yu,GUI Xiao-chuan,HU Mao-ling.An Observation of the effectiveness in the Treatment of Hemoptysis by Fibrinogen and Thrombin via Bronchoscopy[J].Journal of Southern Yangtze University:Natural Science Edition,2003,2(3):327-329.
Authors:ZHOU Min  YUAN Min-yu  GUI Xiao-chuan  HU Mao-ling
Abstract:OBJECTIVE: To search and study a more effective and convenient method in the treatment of hemoptysis. METHOD: 83 cases divided into 4 groups randomly, Gr. 1 fibrinogen and thrombin infused via bronchoscopy; Gr.2 thrombin infused only. Gr.3 vasopressin and antifibrinolysins(PAM-BA and AMCHA) used intravenously. Gr.4 Only antifibinogens(PAMBA and AMCHA) used. RESULT: The treatment effect among the four groups had significant difference statistically ( P = 0.0001) . The treatment effect of Gr. 1 and Gr. 2 was better than that of Gr. 3 and Gr. 4. (P<0.05). The treatment effect of Gr. 1 was better than that of Gr. 2 (P = 0.05). RESULT: The combination of fibrinogen and thrombin used via bronchoscopy ia an effective method in the treatment of hemoptysis, it is better than single drug used.
Keywords:hemoptysis  fiberoptic bronchoscopy  fibrinogen  thrombin
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