Singlet oxygen reactivity of bilirubin and related tetrapyrroles |
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Authors: | D A Lightner Y -T Park |
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Institution: | (1) Department of Chemistry, University of Nevada, 89557 Reno, Nevada, USA |
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Abstract: | Summary The rates of chemical reactivity (kR) and physical quenching (kQ) of singlet oxygen by bilirubin IX , mesobilirubin IX , bilirubin IX dimethyl ester, aetiobilirubin IV , biliverdin IX , biliverdin IX dimethyl ester, aetiobiliverdin IV and an oxodipyrromethene have been determined. The kR and kQ values approach the diffusion threshold for the bilirubin-like substrates, but kRQ by about a factor of 103 for the verdins. A reaction mechanism involving superoxide ion is suggested. Bilirubin appears to quench singlet oxygen by an electron-transfer mechanism.The authors wish to thank the National Science Foundation (CHE 74-20877) and the National Institute of Child Health (HD 09026) for generous support of this work. |
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