芒果苷对自发性高血压大鼠心脑肾组织形态学的影响

观察芒果苷对自发性高血压模型大鼠心、脑、肾等组织形态学特别是炎症损伤的影响,以自发性高血压大鼠(SHR)为研究对象,随机分为模型组、芒果苷高剂量组、芒果苷中剂量组、芒果苷低剂量组和苯那普利组,再以同龄的WKY大鼠作为正常对照。利用光镜、透射电镜观察各组大鼠的心、脑、肾等组织的形态结构。光镜结果显示:脑组织形态学未见明显改变,芒果苷高、中、低剂量组可以改善心肌炎细胞浸润及肾小球萎缩,坏死等。电镜结果显示:芒果苷可以抑制心肌细胞凋亡,改善肌原纤维排列,消除线粒体肿胀,降低系膜细胞及基底膜厚度。说明芒果苷对自发性高血压大鼠心、肾组织形态学具有改善作用,包括对炎症损伤的保护。

The effect of mangiferin on spontaneously hypertensive rat heart, brain and kidney tissue morphology

To observe the effect of mangiferin on the spontaneously hypertensive rats models’ heart,brain,kidney tissue morphology,particularly the inflammatory damage,spontaneously hypertensive rats(SHR) were randomly divided into model group,the mangiferin high dose group,the mangiferin middle dose group,the mangiferin low dose group,and benzene enalapril group,and the same age WKY rats served as normal controls the morphology of each rat’s heart,brain and kidney is used light microscopy,transmission electron microscopy to observe.Light microscopy results show that mangiferin high,middle and low dose group can improve myocarditis cell infiltration and glomerular atrophy,necrosis;electron microscopy results show that mangiferin can inhibite cardiomyocyte apoptosis,improve the muscle fibers,and reduce mesangial cells and basement membrane thickness.It is conclused that mangiferin can protect spontaneously hypertensive rats’ heart,kidney tissue morphology,including the protection of the inflammatory injury.