31P-NMR study on nucleotides and intracellular pH of hereditary spherocytes |
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| Authors: | T Kagimoto F Hayashi M Yamasaki Y Morino K Akasaka S Kishimoto |
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| Institution: | (1) The Second Department of Internal Medicine, Kumamoto University Medical School, 860 Kumamoto, (Japan);(2) Second Department of Biochemistry, Kumamoto University Medical School, 860 Kumamoto, (Japan);(3) Department of Chemistry, Faculty of Science, Kyoto University, 606 Kyoto, (Japan) |
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| Abstract: | Summary As determined by31p-NMR spectroscopy, intracellarar pH of hereditary spherocytes was lower (pH 6.7–6.9) than that of normal red cells. The level of adenosine diphosphate in hereditary spherocytes was found to be persistently high. The metabolism of nucleotides and other phosphoryl compounds in human red blood cells have been studied in detail by31p-NMR spectroscopy1–3. However, to our knowledge, there seems to be no report describing the result of31p-NMR spectroscopy on red blood cells from hereditary spherocytosis. |
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