Relationship between the renal kallikrein activity and the urinary excretion of kallikrein in rats |
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| Authors: | M. Marin-Grez G. Schaechtelin G. Bönner |
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| Affiliation: | (1) Department of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, D-6900 Heidelberg, Germany |
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| Abstract: | Summary Adrenalectomy reduces, and sodium depletion increases, both the daily urinary excretion of kallikrein and the kallikrein activity in the renal cortex. These 2 variables were found to correlate significantly in normal, sodium depleted and adrenalectomized rats, thus supporting the view that kallikrein excretion reflects the activity of the enzyme in the kidney.Acknowledgments. This word was supported by the Deutsche Forschungsgemeinschaft. The technical assistance of Mrs G. Breypohl and Ms J. Kopatsch is gratefully acknowledged. Dr M. Marin-Grez was a fellow of the Alexander von Humbodt Foundation and Dr G. Bönner of the Deutsche Forschungsgemeinschaft. |
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