Theoretical strategies for high-resolution mapping of complex genetic disorders in humans |
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Authors: | Zewei Luo Rongmei Zhang |
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Institution: | (1) Laboratory of Population and Quantitative Genetics, Institute of Genetics, Fudan University, 200433 Shanghai, China |
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Abstract: | Positional cloning of gene(s) underlying a complex disease trait poses requirement of a highresolution linkage map between
the disease locus and genetic marker loci. Recent researches have shown that this may be achieved through appropriately modeling
and screening linkage disequilibrium between the candidate marker locus and the major trait locus. However, these models were
restricted to the circumstances where genotyping at the disease locus was feasible. The major limitations of pedigree-based
linkage analyses were addressed in the light of positional cloning and positional candidate gene identification in humans.
It summarizes the recent efforts in developing theories for fine-scale mapping of genes underlying complex genetic variations
where the one-to-one relationship no longer exists between phenotype of the genetic disorders and the corresponding genotype.
Dedicated to Dr. C. C. Tan for his 90th birthday. |
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Keywords: | positional cloning high-resolution genetic mapping complex genetic traits human |
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