Structure of tumour necrosis factor |
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| Authors: | E Y Jones D I Stuart N P Walker |
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| Institution: | Laboratory of Molecular Biophysics, Oxford, UK. |
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| Abstract: | Tumour necrosis factor is a trimeric molecule, each subunit of which consists of an antiparallel beta-sandwich. Individual subunits from the trimer by a novel edge-to-face packing of beta-sheets. A comparison of the subunit fold with that of other proteins reveals a remarkable similarity to the 'jelly-roll' structural motif characteristic of viral coat proteins. |
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