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Microdialysis study of ischemia-induced hydroxyl radicals in the canine heart |
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| Authors: | A A Timoshin O V Tskitishvili L I Serebryakova A I Kuzmin O S Medvedev E K Ruuge |
| Institution: | (1) Institute of Experimental Cardiology, Cardiology Research Center, Russian Academy of Medical Sciences, 121552 Moscow, (Russia) |
| Abstract: | A new experimental approach for spin-trapping of oxygen radicals in a selected region of the heart in situ is described. This approach is based on microdialysis, and it permits the detection of oxygen radicals in conditions of local ischemia and restoration of normal blood flow. Increased hydroxyl radical generation in an ischemic area of canine myocardium, as a result of 40 min local occlusion, has been studied. |
| Keywords: | Canine heart electron paramagnetic resonance local ischemia microdialysis oxygen radicals spintrapping |
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