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Intracerebroventricular injection of cerebrospinal fluid (CSF) from a patient with congenital indifference to pain induces analgesia in rats |
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| Authors: | A Fabbri F Fraioli G Cruccu M Manfredi C B Pert A Pert |
| Institution: | (1) V. Clinica Medica and V. Clinica Neurologica, Università degli Studi di Roma, Rome, (Italy);(2) Brain Biochemistry Section, Clinical Neuroscience Branch, National Institute of Mental Health, Building 10, Room 3N-212, 20205 Bethesda, Maryland, USA;(3) Biological Psychiatry Branch, National Institute of Mental Health, Building 10, Room 3N-212, 20205 Bethesda, Maryland, USA |
| Abstract: | Summary CSF from a patient with congential indifference to pain was found to produce analgesia in the rat following intracerebroventricular injections. The analgesic effect was attenuated by pretreatment with naloxone suggesting the involvement of hyperactive endogenous opiate mechanisms in this patient. |
| Keywords: | Rat cerebrospinal fluid human analgesia naloxone pain indifference congenital opiates endogenous |
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