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Evolutionary biology: lamprey Hox genes and the origin of jaws
Authors:Cohn Martin J
Affiliation:Division of Zoology, School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading RG6 6AJ, UK. m.j.cohn@reading.ac.uk
Abstract:The development of jaws was a critical event in vertebrate evolution because it ushered in a transition to a predatory lifestyle, but how this innovation came about has been a mystery. In the embryos of jawed vertebrates (gnathostomes), the jaw cartilage develops from the mandibular arch, where none of the Hox genes is expressed; if these are expressed ectopically, however, jaw development is inhibited. Here I show that in the lamprey, a primitively jawless (agnathan) fish that is a sister group to the gnathostomes, a Hox gene is expressed in the mandibular arch of developing embryos. This finding, together with outgroup comparisons, suggests that loss of Hox expression from the mandibular arch of gnathostomes may have facilitated the evolution of jaws.
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