Thrombospondins: from structure to therapeutics |
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| Authors: | D. D. Roberts |
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| Affiliation: | (1) Departments of Biomolecular Chemistry and Medicine, 1300 University Avenue, 4285 Medical Sciences Center, University of Wisconsin, Madison, Wisconsin 53706, USA;(2) Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Research North 270C, Boston, Massachusetts 02215, USA |
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| Abstract: | Thrombospondins are large secreted, multimodular, calcium-binding glycoproteins that have complex roles in mediating cellular processes. Determination of high-resolution structures of thrombospondins has revealed unique and interesting protein motifs. Here, we review this progress and discuss implications for function. By combining structures of modules from thrombospondins and related extracellular proteins it is now possible to prepare an overall model of the structure of thrombospondin-1 and thrombospondin-2 and discern features of other thrombospondins. (Part of a multi-author Review) |
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| Keywords: | Thrombospondin extracellular protein structure cartilage oligomeric matrix protein calcium |
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