Is the variation in the susceptibility of various species to atherosclerosis due to inborn differences in prostacyclin (PGI2) formation? |
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| Authors: | H Sinzinger P Clopath K Silberbauer M Winter |
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| Institution: | (1) Atherosclerosis Research Group at the Department of Medical Physiology, Schwarzspanierstrasse 17, A-1090 Vienna, (Austria);(2) Pharma Research Division, Ciba-Geigy AG, Basle, (Switzerland);(3) 2nd Department of Internal Medicine and 1st Department of Surgery, University of Vienna, Vienna, (Austria) |
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| Abstract: | Summary Species exhibiting a higher susceptibility to the development of atherosclerosis have a reduced prostacyclin (PGI2)-generation in the arterial wall, which differs in various parts of the vascular system. As the difference in PGI2-formation in various diseases is a generalized vascular effect, the changes can be detected in all vessels. This is a very important point for diagnostic purposes in humans.This study was supported by a grant of the «Fonds 600 Jahre Wiener Universität der Kammer der gewerblichen Wirtschaft für Wien». |
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