Structural parts involved in activation and inactivation of the sodium channel |
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| Authors: | W Stühmer F Conti H Suzuki X D Wang M Noda N Yahagi H Kubo S Numa |
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| Institution: | Max-Planck-Institut für biophysikalische Chemie, G?ttingen, FRG. |
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| Abstract: | Structure-function relationships of the sodium channel expressed in Xenopus oocytes have been investigated by the combined use of site-directed mutagenesis and patch-clamp recording. This study provides evidence that the positive charges in segment S4 are involved in the voltage-sensing mechanism for activation of the channel and that the region between repeats III and IV is important for its inactivation. |
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