The processing and presentation of endogenous and exogenous antigen by Schwann cells in vitro |
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Authors: | Lilje O |
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Institution: | (1) School of Biological Sciences, Carslaw (F07), University of Sydney, Sydney N.S.W. 2006 (Australia), Fax +61 2 9351 2175, e-mail: , AU |
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Abstract: | The expression of major histocomatibility complex class II in vitro and in vivo by Schwann cells indicates a potential facultative
role of Schwann cells in the presentation of antigen to neuritogenic T cells during inflammatory demyelinating neuropathies.
Using a T cell proliferation assay, this study demonstrated that processing and presentation of endogenous and exogenous antigen
by Schwann cells influences T cell proliferation. Statistical analysis of proliferation and its relation to processing and
presentation of antigen by Schwann cells had not been previously addressed. Different combinations of factors including treatment
of cultures (untreated, irradiated or fixed), concentration of exogenous antigen (0 or 40 μmg/ml), the presence of interferon-γ
and the timing of exogenous antigen addition influence the proliferation P2-specific, non-mammalian protein ovalbumin-specific T cell lines and naive T cells.
Received 25 July 2002; received after revision 9 September 2002; accepted 7 October 2002 |
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Keywords: | , MHC class II, Schwann cells, endogenous, exogenous, T cell, |
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