Irritant resiniferonol derivatives from EgyptianThymelaea hirsuta L. |
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| Authors: | A M Rizk F M Hammouda S E Ismail M M El-Missiry F J Evans |
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| Institution: | (1) Pharmaceutical Science Laboratory, National Research Centre, Dokki, Cairo, (Egypt);(2) Department of Pharmacognosy, The School of Pharmacy, University of London, 29-39 Brunswick Square, WC1N 1AX London, (England) |
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| Abstract: | Summary Two new aromatic derivatives of 5, 12-dihydroxy-6, 7-epoxy-resiniferonol were isolated from the leaves and twigs ofThymelea hirsuta L. (fam. Thymelaeaceae). These compounds were assigned the structures 12-O-cinnamoyl-5-hydroxy-6, 7-epoxyresiniferonol-9, 13, 14-ortho benzoate 1 and 12-O-heptadecenoyl-5-hydroxy-6, 7,-epoxy-resiniferonol-9, 13, 14-ortho benzoate 2. Both compounds induced erythema of mouse ears in a dose of 0.1  g per ear.Acknowledgments. S. Ismail and M. El-Missiry are grateful to the Royal Society for a travel and support grant. |
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