Prostacyclin-like activity of endothelium and subendothelium — important for atherosclerosis? |
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| Authors: | K Silberbauer H Sinzinger Maya Winter W Feigl F Ring |
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| Institution: | (1) 2nd Department of Internal Medicine, Department of Physiology, Department of Pathology and 2nd Department of Gastroenterology, University of Vienna Medical School, A-1090 Wien, (Austria) |
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| Abstract: | Summary Morphological control of Moncada's bioassay for prostacyclin (PG I2) activity measurement shows that the activity depends not only on endothelium, but in important amounts on subendothelial tissue too. Therefore, it can be concluded that platelet thrombus formation after endothelial cell injury does not depend only on the PG I2-producing ability of the tissue. |
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