Small lymphocyte production and lymphoid cell proliferation in mouse bone marrow |
| |
Authors: | S C Miller M Kaiserman Dr D G Osmond |
| |
Institution: | (1) Department of Anatomy, McGill University, 3640, University Street, H3A 2B2 Montreal, Quebec, (Canada) |
| |
Abstract: | Summary In mice given3H-thymidine systemically during temporary circulatory occlusion of one hind limb, comparison of the labeling of rapidly-renewing small lymphocytes in the tibial marrows demonstrated that these cells were locally produced. Labeling by3H-thymidine infusion revealed that many marrow large lymphoid cells, presumptive small lymphocyte progenitors, had a marked proliferative activity and rapid turnover which varied according to cell size, was maximal in young mice and declined with increasing age.This work was supported by a grant from the Medical Research Council of Canada. The technical assistance of Mrs E. D. Watson is acknowledged. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|