盐酸阿米替林/壳聚糖微球的制备

以一种三环类抗抑郁药盐酸阿米替林为模型药物，采用乳化分散-化学交联法，以乙二醇二缩水甘油醚(ethylene glycol diglycidyl ether，EGDE)为交联剂，制备了盐酸阿米替林壳聚糖微球，考察了其理化性质和释放性能.EGDE 两末端为环氧基团，与氨基反应生成－C－N－键从而起交联作用.所得微球球形规整，呈乳白色，释药速率随CS浓度增大而减慢，在酸性缓冲溶液中略大于碱性缓冲溶液中. 结果表明盐酸阿米替林-壳聚糖微球具有较好的药物缓释性能.

Preparation of Amitriptyline Hydrochloride-Chitosan Microspheres

By using Amitriptyline Hydrochloride as the model drug，amitriptyline hydrochloride-chitosan microspheres were prepared by emulsion cross-linking techniques with ethylene glycol diglycidyl ether （EGDE) as a cross-linking agent. The physicochemical properties and the drug-release performances of the microspheres were investigated. EGDE has epoxy groups and cross-linking reaction occurred with the groups of -NH2 on CS. The microspheres have the color of white, a spherical shape and an average diameter about 12.32m. The drug loaded efficiency is 26.25% and the content of the drug is 6.56%(/). With the increase of the concentration of CS , the releasing ratio of Amitriptyline Hydrochloride decreases. The result indicated that the microspheres have a satisfactory performance of slowly releasing the drug of Amitriptyline Hydrochloride.