| 维药西帕依溃结安灌肠剂对细胞凋亡的影响及其抗溃疡性结肠炎机理 |
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| 引用本文： | 木巴拉克·伊明江,库热西·玉努斯,买吾兰江·依孜布拉,哈木拉提·吾甫尔,李元健. 维药西帕依溃结安灌肠剂对细胞凋亡的影响及其抗溃疡性结肠炎机理[J]. 科技导报(北京), 2011, 29(32): 29-35. DOI: 10.3981/j.issn.1000-7857.2011.32.004 |
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| 作者姓名： | 木巴拉克·伊明江 库热西·玉努斯 买吾兰江·依孜布拉 哈木拉提·吾甫尔 李元健 |
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| 作者单位： | 1. 中南大学湘雅医学院,长沙 410013;2. 新疆医科大学药学院,乌鲁木齐 830011;3. 新疆医科大学基础医学院,乌鲁木齐 830011;4. 新疆医科大学维吾尔医药系,乌鲁木齐 830011 |
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| 摘 要： | 为了揭示维吾尔医学特色药(维药)西帕依溃结安灌肠剂(KJA)在维吾尔医学中用于缓解、治疗溃疡性结肠炎(UC)和抗结肠癌作用及可能机理,选择Wistar大鼠分为正常组、模型组、美沙拉嗪组、KJA加美沙拉嗪组、KJA灌胃组和KJA灌肠组,除正常组外其他组采用DNCB复合乙酸诱导UC模型并实施相应干预。在干预第11,17,24天检测结肠组织形态学及组织病理学评分、结肠细胞凋亡率等指标,进行相同阶段组间及不同阶段组内比较。结果显示,KJA在体能通过改善结肠组织形态学和组织病理学异常改变,选择性诱导炎症细胞凋亡,减轻炎症反应来发挥缓解、治疗UC作用。美沙拉嗪和KJA在治疗UC不同阶段时期对细胞各期凋亡率调节机制可能有差异。其中美沙拉嗪加KJA灌肠治疗对晚期凋亡率效果优于单独使用美沙拉嗪。
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| 关 键 词： | 维药西帕依溃结安灌肠剂 细胞凋亡 机理研究 溃疡性结肠炎 |
| 收稿时间： | 2011-10-29 |
Experimental Study of Effects of Uygur Medicine Xipayi Kuijie'an on Colon Mucosa Apoptosis and the Mechanism of Treating Ulcerative Colitis |
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| IMINJAN Mubarak,YUNUS Kurax,HIZBILLA Mawlanjan,HUPUR Halmurat,LI Yuanjian. Experimental Study of Effects of Uygur Medicine Xipayi Kuijie'an on Colon Mucosa Apoptosis and the Mechanism of Treating Ulcerative Colitis[J]. Science & Technology Review, 2011, 29(32): 29-35. DOI: 10.3981/j.issn.1000-7857.2011.32.004 |
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| Authors: | IMINJAN Mubarak YUNUS Kurax HIZBILLA Mawlanjan HUPUR Halmurat LI Yuanjian |
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| Affiliation: | 1. Xiang Ya Medical Institute, Central South University, Changsha 410013,China;2. College of Pharmacy, Xinjiang Medical University, Urumqi 830011, China;3. College of Basic Medicine, Xinjiang Medical University, Urumqi 830011, China;4. Traditional Uygur Medicine Department, Xinjiang Medical University, Urumqi 830011, China |
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| Abstract: | To investigate the efficiency and the mechanism of the Uygur herb medicine Turkish Gall aqueous(KJA) in treating Ulcerative colitis and Colon cancer, we detect in vitro HT-29 cell apoptotic rate intervened by different concentrations of KJA and in vivo DNCB plus acetic acid induced UC's model rat apoptotic rate, morphological, pathological CMDI grading score changes of colon mucosa after being intervened by KJA. The results were compared between the normal group, the model control group, the mesalazine positive control group, the mesalazine plus KJA group, the KJA gavage group and the KJA enema group in three courses of treatment. It is demonstrated that the KJA would possibly have a therapeutic function in vitro to Colon cancer HT-29 cell by inducing cell apoptosis rate and in vivo to UC in rat by reducing colon mucosa morphological, pathological abnormal damages and inducing the apoptosis rate of colon mucosa damaged cells. |
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| Keywords: | Uygur medicine Xipayi Kuijie'an enema cell apoptotic mechanism research ulcerative colitis |
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