维药异常黑胆质成熟剂对异常黑胆质载体大鼠动物模型血液流变学指标的影响

 为了观察异常黑胆质成熟剂对异常黑胆质载体大鼠动物模型血液流变性及凝血功能的作用,选用健康Wistar大鼠,分为正常对照组、异常黑胆质模型组、药物干预组、自然恢复组,测定4组全血黏度、血浆黏度、全血还原黏度、红细胞聚集指数、变形指数、刚性指数、电泳指数、红细胞压积和血浆凝血酶原时间(PT),纤维蛋白原(FIB),活化部分凝血活酶时间(APTT)和血浆凝血酶时间(TT)等血液流变学指标并分析。结果显示,异常黑胆质成熟剂能有效控制异常黑胆质证大鼠模型血液黏度增高及凝血功能异常。

Hemorheological Effects of Abnormal Savda Munziq,as a Traditional Uighur Medicine,on the Abnormal Savda Rat Model

The hemorheological and coagulation effects of Abnormal Savda Munziq (ASM), as an herbal preparation used in Traditional Uighur Medicine, on the abnormal savda rat model are investigated. The level of whole blood viscosity, plasma viscosity, whole blood reduced viscosity, erythrocyte aggregation index, deformation index, rigidity index, electrophoresis index, hematocrit, and other indicators were determined by the LBY-N6B instrument. The level of PT, FIB, TT, and APTT were measured by automated blood coagulation analyzer. The results are as follows: (1) Compared with control group, the whole blood viscosity (low, moderate, and higher shear rate), plasma viscosity are significantly higher in the model group (P<0.05); The erythrocyte rigidity index and erythrocyte deformability index decrease significantly (P<0.05); The thrombin time shortens and FIB increases significantly (P<0.01 respectively); The erythrocyte aggregation index difference is not remarkable (P>0.05); (2) Compared with model group, for the medicine intervention group, whole blood viscosity with low shear rate, whole blood viscosity with moderate shear rate, and whole blood reduced viscosity with moderate and higher shear rate are lower than those in the control group and natural recovery group (P<0.05), respectively; The erythrocyte rigidity index and erythrocyte deformability index increase significantly (P<0.05); The thrombin time shorten could be effectively controlled in the medicine intervention group (P<0.01). The result indicates that the ASM could effectively control the blood hyperviscosity and dysfunction of blood coagulation of abnormal savda syndrome rat model.