The delta sleep inducing peptide (DSIP). Comparative properties of the original and synthetic nonapeptide |
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| Authors: | M Monnier L Dudler R Gächter P F Maier H J Tobler G A Schoenenberger |
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| Institution: | (1) Present address: Physiological Institute, University of Basel, Vesalgasse 1, CH-4051 Basel, (Switzerland);(2) Present address: Research Division, Department of Surgery, Kantonsspital Basel, CH-4031 Basel, (Switzerland) |
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| Abstract: | Summary Both the original and the synthetic nonapeptide Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu enhance, in recipient rabbits, spindle and delta EEG activity as in orthodox slow wave sleep.Acknowledgment. This work was supported by grants from the Swiss National Foundation for Scientific Research (No. 3.871.72, 3.527.75,3.443.074, 3.780.076), Fonds für Lehre und Forschung der Universität Basel, Merck Sharp and Dohme (USA), Ciba-Stiftung Basel, Hoffmann La Roche Ltd Basel, Sandoz Ltd Basel. We received valuable help from Dr S. Roncari, Dr B. Wilson and Dr C. D. Bennett for chemical research, and from Prof. A. Cerletti, Dr H. J. Tobler and Mr J. J. Regez (Division of Application and Research Development, Sandoz Ltd) for data processing. |
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