Metaraminol uptake by human thrombocytes: A poor model for neuronal noradrenaline uptake |
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Authors: | P C Waldmeier P A Baumann |
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Institution: | (1) Research Department, Pharmaceuticals Division, CIBA-GEIGY Ltd, CH-4002 Basel, Switzerland |
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Abstract: | Summary The IC50 of a number of antidepressants and related drugs on the uptake of 1-metaraminol and serotonin into human thrombocytes, and of noradrenaline and serotonin into rat midbrain synaptosomes were compared. In accordance with previous reports, it was found that platelets, provide a good model for the study of neuronal uptake of serotonin. Platelet uptake of 1-metaraminol, although correlated to some extent with noradrenaline uptake into synaptosomes, seems to be an unsatisfactory model for the neuronal uptake of the latter amine. |
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