Chlorinated benzene induction of hepatic porphyria |
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| Authors: | G. P. Carlson |
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| Affiliation: | (1) Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal Sciences, Purdue University, 47907 West Lafayette, Indiana, USA |
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| Abstract: | Summary 1,4-Dichlorobenzene and 1,2,4-trichlorobenzene were compared with hexachlorobenzene which is known to cause porphyria. Although hexachlorobenzene administration resulted in a manyfold increase in liver porphyrin levels and urinary excretion of porphyrins, the lesser chlorinated compounds did not do so.Supported by grant R804328 from the US Environmental Protection Agency. |
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