| 安乃近的普鲁士蓝分光光度法测定 |
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| 引用本文： | 刘荣森,张长水. 安乃近的普鲁士蓝分光光度法测定[J]. 河南师范大学学报(自然科学版), 2015, 0(2): 94-97 |
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| 作者姓名： | 刘荣森 张长水 |
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| 作者单位： | 河南林业职业学院;河南科技大学化工与制药学院 |
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| 基金项目： | 国家自然科学基金(1105130) |
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| 摘 要： | 基于安乃近能将Fe3+还原为Fe2+,Fe2+与铁氰化钾生成可溶性普鲁士蓝,建立了用可见分光光度法间接测定安乃近的新方法.对反应时间和反应温度进行了优化,安乃近浓度在0.06~7.20μg/mL范围内具有良好的线性关系,线性回归方程为A=0.0218+0.2394 C(μg/mL),相关系数R=0.999.摩尔吸光系数ε=8.4×104 L/(mol·cm).检测限(3σ/k)为0.024μg/mL.按照本法对市售安乃近片进行了测定,并进行了回收率实验,平均回收率为100.8%,结果令人满意.
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| 关 键 词： | 安乃近 普鲁士蓝 分光光度法 |
Quantitative Determination of Analgin in Tablets by Prussian Blue Spectrophotometry |
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| LIU Rongsen;ZHANG Changshui. Quantitative Determination of Analgin in Tablets by Prussian Blue Spectrophotometry[J]. Journal of Henan Normal University(Natural Science), 2015, 0(2): 94-97 |
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| Authors: | LIU Rongsen ZHANG Changshui |
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| Affiliation: | LIU Rongsen;ZHANG Changshui;Henan Forestry Vocational College;College of Chemical Engineering and pharmaceutics,Henan University of Science and Technology; |
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| Abstract: | Based on our experiments,Fe3+ can be reduced into Fe2+ by analgin component.The Fe2+can further react with K3[Fe(CN)6]to form a soluble compound with Prussian blue.We developed a new method to determine analgin in a drug tablet.After optimization of reaction time and temperature,agood linear relationship was obtained in concentrations of 0.06~7.20μg/mL.A regression equation was obtained as A=0.0218+0.2394C(μg/mL).A correlation coefficient of 0.999,an apparent molar absorption coefficient of 8.4×104 L/(mol·cm),and a detection limit of 0.024μg/mL were obtained.An average recovery of 100.8% was achieved.Finally,we quantitatively determined the analgin in several drug tablets,and the result is satisfied. |
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| Keywords: | analgin Prussian blue spectrophotometry |
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