| 蝙蝠葛酚性碱对胃癌细胞SGC-7901 COX-2表达的影响 |
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| 引用本文： | 章艳,苏慧,苏云明. 蝙蝠葛酚性碱对胃癌细胞SGC-7901 COX-2表达的影响[J]. 哈尔滨商业大学学报(自然科学版), 2014, 0(6): 653-654 |
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| 作者姓名： | 章艳 苏慧 苏云明 |
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| 作者单位： | 黑龙江中医药大学,哈尔滨,150040 |
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| 基金项目： | 黑龙江省中医管理局( ZHY12-2059);黑龙江中医药大学‘优秀创新人才支持计划’科研项目． |
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| 摘 要： | 为探讨蝙蝠葛酚性碱(PAMD)抗胃癌的作用机理,通过实时定量PCR观察PAMD对胃癌细胞株SGC-7901 COX-2 mRNA表达的影响.结果表明,PAMD各剂量组均能下调COX-2 mRNA的表达,其中PAMD(20)剂量组下调COX-2的作用有统计学差异,且优于阳性对照组.PAMD抗胃癌的作用机理可能与其抑制COX-2基因表达有关.
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| 关 键 词： | 蝙蝠葛酚性碱 胃癌 SGC-7901 COX-2 |
Effects of Phenolic alkaloids from Menisphermum dauricum on COX-2 of gastric cancer cell SGC-7901 |
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| ZHANG Yan,SU Hui,SU Yun-ming. Effects of Phenolic alkaloids from Menisphermum dauricum on COX-2 of gastric cancer cell SGC-7901[J]. Journal of Harbin University of Commerce :Natural Sciences Edition, 2014, 0(6): 653-654 |
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| Authors: | ZHANG Yan SU Hui SU Yun-ming |
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| Affiliation: | ( Heilongjiang University of Chinese Medicine, Herbin 150040, China) |
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| Abstract: | To study inhibition mechanism of gastric cancer of Phenolic alkaloids from Menisphermum dauricum（PAMD） the effect PAMD on mRNA expression of COX-2 of human gastric cancer cell SGC-7901 was observed by Real-time PCR. The results indicated that PAMD groups were able to cut the mRNA expression of COX-2,and PAMD（20） group significantly reduced the COX-2 and better than the positive control. The mechanism may be related to its inhibition of COX-2 gene expression. |
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| Keywords: | Phenolic alkaloids from Menispermum dauricum (PAMD) gastric cancer SGC-7901 COX-2 |
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