An important functional group,benzo[1,3]dioxole,of alkaloids induces the formation of the human telomeric DNA G-quadruplex |
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Authors: | Shu Yang JunFeng Xiang QianFan Yang QiuJu Zhou XiuFeng Zhang Qian Li YaLin Tang GuangZhi Xu |
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Affiliation: | (1) Beijing National Laboratory for Molecular Sciences, Centre for Molecular Sciences, State Key Laboratory for Structural Chemistry for Unstable and Stable Species; Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China;(2) Graduate University of Chinese Academy of Sciences, Beijing, 100049, China; |
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Abstract: | Over the past few decades, numerous molecules have been discovered or designed to interact efficiently and selectively with a peculiar DNA structure named G-quadruplex. Some of these molecules have been developed as anticancer agents. To aid the design of anticancer agents, the ability of alkaloids possessing Protoberberine and Benzophenanthridine groups to induce the formation of G-quadruplexes were studied using CD spectroscopy. By careful examination of their structures, we found that a benzo[1,3]dioxole group plays an important role in influencing their inductive properties. The more functional groups the alkaloids have, the stronger their G-quadruplex inductive ability. |
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Keywords: | benzo[1 3]dioxole group telomeric DNA G-quadruplex alkaloids Protoberberine Benzophenanthridine |
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