| 硅溶胶对硫酸庆大霉素的吸附和缓释 |
| |
| 引用本文： | 宋美荣,杨静,崔淑敏,门宝.硅溶胶对硫酸庆大霉素的吸附和缓释[J].河南科学,2008,26(9). |
| |
| 作者姓名： | 宋美荣 杨静 崔淑敏 门宝 |
| |
| 作者单位： | 1. 河南农业大学,理学院,郑州,450002
2. 河南中医学院,药学院,郑州,450008 |
| |
| 基金项目： | 河南农业大学博士科研启动基金，国家自然科学基金 |
| |
| 摘 要： | 以单分散性好、粒径在20nm左右的二氧化硅(SiO2)溶胶为药物载体,制备了负载硫酸庆大霉素的载药纳米硅凝胶.通过红外光谱以及紫外可见吸收光谱考察了硅溶胶对硫酸庆大霉素的吸附和释放性能.结果表明,硅溶胶对硫酸庆大霉素有较大的吸附率(89.6%)和载药量(59.9%),以及较慢的缓释性能(48h内释放79.6%),作为药物载体是可行的.
|
| 关 键 词： | 硅溶胶 硫酸庆大霉素 吸附 缓释 |
Adsorption and Release of Gentamicin Sulfate for Silica Sol |
| |
| Song Meirong,Yang Jing,Cui Shumin,Men Bao.Adsorption and Release of Gentamicin Sulfate for Silica Sol[J].Henan Science,2008,26(9). |
| |
| Authors: | Song Meirong Yang Jing Cui Shumin Men Bao |
| |
| Institution: | Song Meirong1,Yang Jing2,Cui Shumin1,Men Bao1 (1. School of Science,Henan Agricultural University,Zhengzhou 450002,China,2. Pharmacy College,Henan University of Traditional Chinese Medicine,Zhengzhou 450008,China) |
| |
| Abstract: | Silica sol with high mono-dispersibility and an average particle size of 20 nm were used for the carrier of gentamicin sulfate. The adsorption of gentamicin sulfate on sol and the in vitro release rate of gentamicin sulfate from silica sol was studied on infrared and ultraviolet-visible spectrophotometry,respectively. The results indicate that silica sol has a higher drug adsorption rate(89.6 %)and carrier rate(59.9 %)and lower release rate (79.6 % released in 48 h),so it is feasible for silica sol to be us... |
| |
| Keywords: | silica sol gentamicin sulfate adsorption release |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
