| 促红细胞生成素与中枢神经系统损伤 |
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| 引用本文： | 高荣莲,陈肖华,王丽峰.促红细胞生成素与中枢神经系统损伤[J].科学技术与工程,2004,4(7):556-561. |
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| 作者姓名： | 高荣莲 陈肖华 王丽峰 |
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| 作者单位： | 军事医学科学院放射医学研究所,北京,100850 |
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| 基金项目： | 国家自然科学基金(40172101) |
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| 摘 要： | 1989年促红细胞生成素(erythropoietin，EPO)开始应用于临床，但它的应用范围主要局限于治疗各类贫血，如肾性贫血、爱滋病患者贫血、癌症相关贫血等。近年的研究发现，EPO在中枢神经系统内也有大量的分布，并且有其受体的广泛表达。脑源性EPO的生成受多种因素的影响。EPO具有营养神经的功能，并且在中枢神经系统的发生发育、神经功能的维持以及多种神经系统损伤中有着重要作用。
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| 关 键 词： | 促红细胞生成素 中枢神经系统 凋亡 |
| 文章编号： | 1671-1815(2004)07-0556-06 |
| 修稿时间： | 2004年3月17日 |
The Effect of Erythropoietin on the Central Nervous System Injury |
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| GAO Ronglian,CHEN Xiaohu,WANG Lifeng Institute of Radiation Medicine,Academy of Military Medical Science,Beijing.The Effect of Erythropoietin on the Central Nervous System Injury[J].Science Technology and Engineering,2004,4(7):556-561. |
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| Authors: | GAO Ronglian CHEN Xiaohu WANG Lifeng Institute of Radiation Medicine Academy of Military Medical Science Beijing |
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| Institution: | GAO Ronglian,CHEN Xiaohua,WANG Lifeng Institute of Radiation Medicine,Academy of Military Medical Science,Beijing 100850 |
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| Abstract: | Since 1989 erythropoietin has been used safely and effectively for over decade for the treatment of anemia related to a variety of disorders, including chronic renal failure, antiretroviral therapy for HIV infection, and cancer chemotherapy, etc. Recently, it has been showed that EPO and its receptor are distributed in the Central Nervous System(CNS) extensively. Nerve derived EPO is affected by many factors. EPO has important functions in neurous nutrition, development of the CNS and the CNS injury and so on. |
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| Keywords: | erythropoietin the central neurous system apoptosis |
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